IMMUN & CELL + NUKLEOTIDE

<div class="zutaten">
<h3>Zutaten:</h3>
<p><strong>Inhaltsstoffe:</strong><br>
Nukleotide 22 % (Natriumsalze der AMP, CMP, GMP, IMP und UMP); L-Methionin; L-Lysin; Nährhefe (inaktiviert); Hydroxypropylmethylcellulose;
Vitamin C (L-Ascorbinsäure); Füllstoff (Cellulose); Inositol; Säureregulator (Natriumcitrate); Vitamin E
(DL-α-Tocopherylacetat); Calcium-D-pantothenat; (6S)-5-Methyltetrahydrofol-säure, Glucosaminsalz; D-Biotin; Vitamin B12
(Cyanocobalamin).</p>

<p>vegan, glutenfrei, laktosefrei</p>

<p><strong>Inhalt:</strong><br>
60 Kapseln</p>

<p><strong>Hinweis:</strong><br>
Ausserhalb der Reichweite von kleinen Kindern aufbewahren. Die angegebene empfohlene Tagesdosis nicht überschreiten. Nahrungsergänzungsmittel sind kein Ersatz für eine abwechslungsreiche Ernährung. Kühl und trocken lagern.</p>
</div>

<div class="naehrwerte">
<h3>Durchschnittliche Nährwerte<br>
<strong>Immun & Cell + Nukleotide</strong></h3>

<table class="nwtabelle">
<tr>
<th class="tg-031e">Vitamin</th>
<th class="tg-031e">Pro 1000 mg<br>(Tagesdosis: 2 Kapseln)</th>
<th class="tg-031e">Gehalt in % NRV*</th>
</tr>
<tr>
<td class="nw-titel">Vitamin C</td>
<td class="nw-wert">56,0 mg</td>
<td class="nw-wert">70</td>
</tr>
<tr>
<td class="nw-titel">Folat</td>
<td class="nw-wert">120,0 µg</td>
<td class="nw-wert">60</td>
</tr>
<tr>
<td class="nw-titel">Pantothensäure</td>
<td class="nw-wert">3,6 mg</td>
<td class="nw-wert">60</td>
</tr>
<tr>
<td class="nw-titel">Biotin</td>
<td class="nw-wert">35,0 µg</td>
<td class="nw-wert">70</td>
</tr>
<tr>
<td class="nw-titel">Vitamin E</td>
<td class="nw-wert">8,4 mg</td>
<td class="nw-wert">70</td>
</tr>
<tr>
<td class="nw-titel">Vitamin B12</td>
<td class="nw-wert">1,5 µg</td>
<td class="nw-wert">60</td>
</tr>
</table>
<p><em>*) Nährstoffbezugswerte (nutrient reference values, NRV)</em></p>
</div>

<h3>Quellen und wissenschaftliche Untersuchungen zu Nukleotiden als Nahrungsergänzung:</h3>
<ul class="list-check-icon-small">

<li> <a>Dietary nucleotides reverse malnutrition and starvation-induced immunosuppression.</a> Pizzini RP, Kumar S, Kulkarni AD, Rudolph FB, Van Buren CT. Arch Surg. 1990 Jan;125(1):86-9; discussion 90. doi: 10.1001/archsurg.1990.01410130092012. PMID: 1688491</li>
<li> <a>Dietary nucleotides correct plasma and liver microsomal fatty acid alterations in rats with liver cirrhosis induced by oral intake of thioacetamide. </a>Fontana L, Moreira E, Torres MI, Fernández I, Ríos A, Sánchez de Medina F, Gil A. J Hepatol. 1998 Apr;28(4):662-9. doi: 10.1016/s0168-8278(98)80291-2. PMID: 9566836</li>
<li> <a>Effect of dietary nucleotides on intestinal repair in rats with experimental chronic diarrhea. </a>Nuñez MC, Ayudarte MV, Morales D, Suarez MD, Gil A. JPEN J Parenter Enteral Nutr. 1990 Nov-Dec;14(6):598-604. doi: 10.1177/0148607190014006598. PMID: 2125643</li>

<li><a>Dietary nucleotides: cellular immune, intestinal and hepatic system effects.</a> Carver JD. J Nutr. 1994 Jan;124(1 Suppl):144S-148S. doi: 10.1093/jn/124.suppl_1.144S. PMID: 8283305 Review.</li>
<li> <a>Dietary nucleotides: a conditional requirement.</a> Van Buren CT, Rudolph F. Nutrition. 1997 May;13(5):470-2. doi: 10.1016/s0899-9007(97)00103-2. PMID: 9225342 Review. No abstract available.</li>
<li><a>Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats.</a> Cai X, Bao L, Wang N, Ren J, Chen Q, Xu M, Li D, Mao R, Li Y. Food Funct. 2016 Jun 15;7(6):2898-908. doi: 10.1039/c5fo01580d. Epub 2016 Jun 1. PMID: 27247978</li>
<li> <a>Modulation of the immune response mediated by dietary nucleotides.</a> Gil A. Eur J Clin Nutr. 2002 Aug;56 Suppl 3:S1-4. doi: 10.1038/sj.ejcn.1601475. PMID: 12142952 Review.</li>
<li> <a>Dietary nucleotides extend the life span in Sprague-Dawley rats.</a> Xu M, Liang R, Guo Q, Wang S, Zhao M, Zhang Z, Wang J, Li Y. J Nutr Health Aging. 2013 Mar;17(3):223-9. doi: 10.1007/s12603-012-0399-z. PMID: 23459974</li>
<li> <a>Why are dietary nucleotides essential nutrients?</a> Grimble GK. Br J Nutr. 1996 Oct;76(4):475-8. doi: 10.1079/bjn19960056. PMID: 8942356 No abstract available.</li>
<li> <a>Dietary nucleotides enhance the liver redox state and protein synthesis in cirrhotic rats.</a> Pérez MJ, Sánchez-Medina F, Torres M, Gil A, Suárez A. J Nutr. 2004 Oct;134(10):2504-8. doi: 10.1093/jn/134.10.2504. PMID: 15465738</li>
<li> <a>Nonimmune system responses to dietary nucleotides.</a> Uauy R. J Nutr. 1994 Jan;124(1 Suppl):157S-159S. doi: 10.1093/jn/124.suppl_1.157S. PMID: 8283307 Review.</li>
<li> <a>Dietary nucleotides have cytoprotective properties in rat liver damaged by thioacetamide.</a> Torres MI, Fernández MI, Gil A, Ríos A. Life Sci. 1998;62(1):13-22. doi: 10.1016/s0024-3205(97)01033-3. PMID: 9444963</li>
<li> <a>Effect of dietary nucleotides on small intestinal repair after diarrhoea. Histological and ultrastructural changes. </a> Bueno J, Torres M, Almendros A, Carmona R, Nuñez MC, Rios A, Gil A. Gut. 1994 Jul;35(7):926-33. doi: 10.1136/gut.35.7.926. PMID: 8063220 Free PMC article.</li>
<li> <a>Effect of dietary nucleotides on degree of fibrosis and steatosis induced by oral intake of thioacetamide. </a>Torres MI, Fernandez MI, Gil A, Rios A. Dig Dis Sci. 1997 Jun;42(6):1322-8. doi: 10.1023/a:1018882913983. PMID: 9201102 </li>
<li> <a>Effects of dietary nucleotides on lipid metabolism and learning ability of rats.</a> Sato N, Murakami Y, Nakano T, Sugawara M, Kawakami H, Idota T, Nakajima I. Biosci Biotechnol Biochem. 1995 Jul;59(7):1267-71. doi: 10.1271/bbb.59.1267. PMID: 7670187 Free article.</li>
<li> <a>Effect of dietary nucleotides on immune function in Balb/C mice.</a> Xu M, Zhao M, Yang R, Zhang Z, Li Y, Wang J. Int Immunopharmacol. 2013 Sep;17(1):50-6. doi: 10.1016/j.intimp.2013.04.032. Epub 2013 May 10. PMID: 23669334</li>

<li> <a>Dietary nucleotides accelerate intestinal recovery after food deprivation in old rats.</a> Ortega MA, Nunez MC, Gil A, Sánchez-Pozo A. J Nutr. 1995 Jun;125(6):1413-8. doi: 10.1093/jn/125.6.1413. PMID: 7782893</li>
<li> <a>Dietary nucleotides augment dextran sulfate sodium-induced distal colitis in rats.</a> Sukumar P, Loo A, Adolphe R, Nandi J, Oler A, Levine RA. J Nutr. 1999 Jul;129(7):1377-81. doi: 10.1093/jn/129.7.1377. PMID: 10395601</li>
<li> <a>Effect of dietary nucleotides on response to bacterial infections.</a> Kulkarni AD, Fanslow WC, Rudolph FB, Van Buren CT. JPEN J Parenter Enteral Nutr. 1986 Mar-Apr;10(2):169-71. doi: 10.1177/0148607186010002169. PMID: 2421021</li>
<li> <a>Maturation status of small intestine epithelium in rats deprived of dietary nucleotides.</a> Ortega MA, Gil A, Sánchez-Pozo A. Life Sci. 1995;56(19):1623-30. doi: 10.1016/0024-3205(95)00129-t. PMID: 7723591</li>
<li><a>Dietary Nucleotides Retard Oxidative Stress-Induced Senescence of Human Umbilical Vein Endothelial Cells.</a> Zhu N, Liu X, Xu M, Li Y. Nutrients. 2021 Sep 20;13(9):3279. doi: 10.3390/nu13093279. PMID: 34579157 Free PMC article.</li>
<li><a>Dietary Nucleotides Supplementation and Liver Injury in Alcohol-Treated Rats: A Metabolomics Investigation.</a> Cai X, Bao L, Wang N, Xu M, Mao R, Li Y. Molecules. 2016 Mar 31;21(4):435. doi: 10.3390/molecules21040435. PMID: 27043516 Free PMC article.</li>
<li><a>Dietary nucleotides and gut mucosal defence.</a> Grimble GK. Gut. 1994 Jan;35(1 Suppl):S46-51. doi: 10.1136/gut.35.1_suppl.s46. PMID: 8125390 Free PMC article. Review.</li>
<li> <a>Dietary nucleotides: effects on the immune and gastrointestinal systems.</a> Carver JD. Acta Paediatr Suppl. 1999 Aug;88(430):83-8. doi: 10.1111/j.1651-2227.1999.tb01306.x. PMID: 10569229 Review.</li>
<li><a>Anti-fatigue effects of dietary nucleotides in mice.</a> Xu M, Liang R, Li Y, Wang J. Food Nutr Res. 2017 Jun 14;61(1):1334485. doi: 10.1080/16546628.2017.1334485. eCollection 2017. PMID: 28659748 Free PMC article.</li>

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