Your Strong WallYour intestinal wall—made up of cells—is constantly renewing itself. It needs healthy cells and forms a natural barrier against toxins, viruses, and bacteria.
Your intestinal cells regenerate every 3–5 days. Give them the building blocks they need.
Nucleotides for Gut Health: What the Studies Show
- The Right Building Blocks—for Targeted Support—Nucleotides, Vitamins with Specific Amino Acids**
- The basis ofall cell division** — Detox or intestinal cleanse—large numbers of new cells are needed
- Swiss Premium Quality—individually selected nucleotides in a scientifically tested formula
Starting at 1.69 €/CHF per day · Delivery in 2–3 business days · Made in Switzerland
4,9
4.9 out of 5 stars
240+ verified reviews
Traditional colon cleanses provide bacteria—but not the building blocks your intestinal lining needs to regenerate. Colon & Cell provides exactly those building blocks: high-purity nucleotides, developed in Switzerland.
The "Aha!" Moment
Why Bacteria Alone Are Not Enough
Imagine your intestinal wall as a protective wall. Probiotics—the bacteria in your gut flora (your microbiome) found in traditional gut cleanses—are good tenants living on this wall. But the wall itself is made of bricks: your intestinal cells.
And this wall is constantly being rebuilt. Your intestinal lining renews itself every 3–5 days—no other tissue in the body works at this pace. For every new brick, your body needs nucleotides, the basic building blocks of every cell.
In normal times, the body obtains it from three sources: de novo synthesis, the recycling of old cells, or food. But during times of stress, after infections, or following antibiotic treatment, the demand skyrockets—and that is precisely when the building material is often in short supply.
Colon & Cell fills this gap: highly pure, individually selected nucleotides with very high bioavailability** — supplemented with B vitamins and amino acids.
These building blocks are essential if you want to specifically build up your gut flora:
Your Healthy TenantsHealthy gut bacteria also need to be treated well. Studies suggest that nucleotides act as growth factors for bifidobacteria and lactobacilli.
Your durable bricksNucleotides—the building blocks of the wall—are needed in very large quantities. An adequate supply ensures that all processes in the body run smoothly.
30 Years of Nucleotide Research
Developed by Dr. Peter Köppel
The combination of nucleotides in Colon & Cell is modeled after breast milk—this ensures that the building blocks reach the areas of the intestinal wall where they are needed for cell regeneration.**
Dr. Peter Köppel Biochemist & Immunologist, Nucleotide Researcher — Developer of Colon & Cell
Your Start
Choose your course
Both packages contain the same formula—you just choose how long you want to keep your cells nourished.
The 20-Day Cell Detox
CHF 34.50CHF 36.90
CHF 1.73 per day
You'll save CHF 2.40The perfect time to get to know it—a full cycle of renewal for your intestinal lining.
The 80-Day Wellness Program
CHF 134.70CHF 147.60
CHF 1.68 per day
You'll save CHF 12.90For a complete cell renewal routine—day after day, without interruption.
30-Day Money-Back Guarantee · Payment options include TWINT and credit/debit cards · Ships in 2–3 business daysSee more sizes in the store →
Your Daily Life
What's Changing for You
Peace of Mind
A healthy mucous membrane** is the foundation of stable, relaxed digestion—day after day.
Detox Program and Recovery After Taking Antibiotics
Nutrients for the phase when your gut needs support: Folate contributes to normal cell division.**
Energy That Makes a Difference
Biotin and folate contribute to normal energy metabolism and help reduce fatigue** — something you can really feel in your everyday life.
SWAP-SLOT · Expert Photo
Recommendation Based on Practical Experience
Why I Recommend Colon & Cell
Especially when supporting clients after antibiotic treatment or during a detox program, I see just how important these building blocks are for my clients’ overall gut health—and that’s exactly where Colon & Cell comes in.**
Heinz Wattenhofer, lic., lic. phil. I Body therapist, psychotherapist, breath therapist, and expert in gut health
The Formula
Five building blocks, one system
Each nucleotide plays a specific role in cell structure. Colon & Cell combines all five—individually selected and in a highly pure form.
The Cell Battery
Adenosine (AMP)
Serves as a building block of RNA, as a precursor in energy metabolism, and as a signaling molecule. Provides the cell's energy currency—the foundation for the mucous membrane and blood supply to the intestinal wall.
Adenosine monophosphate
The Shield Builder
Uridine (UMP)
Supports the regeneration of nerve fibers, promotes the formation of cell membranes, and helps improve signal transmission. It plays a role in building the outermost mucus layer—your gut’s first line of defense.
Uridine monophosphate
The Tissue Repairer
Cytidine (CMP)
Serves as a building block (nucleotide) for ribonucleic acid, which is used to store and transmit genetic information. A building block of new cell membranes—needed when tissue regenerates after infections or antibiotic treatment.
Cytidine monophosphate
The Immune Guardian
Guanosine (GMP)
is a key building block for the synthesis of ribonucleic acid (RNA), which is necessary for protein production in cells. It supports cellular signaling pathways—about 70% of your immune cells are located in the gut.
Guanosine monophosphate
The Turbo Master
Inosine (IMP)
Serves as a building block (precursor) in the body for the formation of adenosine and guanosine nucleotides, which are important for cellular energy (ATP). A building block for rapid cell division** — wherever tissue is rapidly regenerating.
Inosine monophosphate
It's that easy
Your Treatment in Three Steps
3 capsules daily
With a meal, along with a glass of water—that's it.
20 days in a row
Your gut renews itself in cycles—consistency matters more than quantity.
Stay on top of it
Many people make the workout a regular part of their routine—your rhythm, your pace.
Recommended intake according to the label: 3 capsules daily. Do not exceed the recommended daily dose.
Customer ratings
4.9 out of 5 stars
"A fantastic product that gives you an instant energy boost. We've been able to handle our usual daily work routine much better since we started taking the nucleotides. I also feel that after dental surgery and taking antibiotics, my gut—and therefore I myself—recovered much faster than usual. We'll definitely keep using it. Thanks for this great product!"
Rita K. Verified Purchase
“Generally speaking, I feel better when I take nucleotides—I have more energy and a greater zest for life. Maybe I’m getting so used to feeling this good that I hardly notice it anymore. I’ve been taking them since October 2023, after Dr. Köppel introduced them at Lucia Treffurth. I recently started drinking the protein shake again. I was practically bursting with energy. Now I’m on my second can. I always look forward to it, but the overwhelming energy has subsided.”
Gisela W. Verified Purchase
"I'm not just satisfied—I'm thrilled with Cool & Cell. My metabolism has improved tremendously. And I attribute that to Cool & Cell ;)
It's indispensable to me ;) Huge kudos to the developer ;) TOP product!"
Edith S. Verified Purchase
Press & Media
As seen in the media
FOCUS online and CHIP have published articles on nucleotides and longevity — read the articles.
Scientific Classification: Selected Sources
The following studies examine nucleotides as a class of compounds, not *Colon & Cell*. Most of the data comes from studies of infants as well as from animal and laboratory experiments; there are very few meaningful studies on the gut in healthy adults. The studies are intended for scientific classification and should be considered independently of this dietary supplement.
Review Articles
Hess JR, Greenberg NA (2012). The role of nucleotides in the immune and gastrointestinal systems: potential clinical applications. Nutrition in Clinical Practice 27(2):281–294. DOI · PubMed
Study type: Review. Nucleotides from the diet play an important role in rapidly dividing cells and are considered conditionally essential when there is an increased need (e.g., growth, injury, or infection). In infant formula, they have been reported to promote improved intestinal maturation and immune function. The authors consider conclusions regarding specific benefits of individual nucleotides to be limited.
Uauy R, Quan R, Gil A (1994). Role of nucleotides in intestinal development and repair: implications for infant nutrition. Journal of Nutrition 124(8 Suppl):1436S–1441S. DOI · PubMed
Study type: Review. Rapidly growing tissues such as the intestinal epithelium and lymphatic cells have a limited ability to synthesize nucleotides on their own and require exogenous purine and pyrimidine bases. Nucleotides are considered important for the development, maturation, and repair of the gastrointestinal tract. Excess purines are broken down into uric acid. Breast milk is considered the best source of nucleotides for young infants.
Grimble GK (1994). Dietary nucleotides and gut mucosal defense. Gut 35(1 Suppl):S46–S51. DOI · PubMed
Study type: Review. The gut relies on a supply of nucleotides that are synthesized anew in the liver. Humans adapt their endogenous synthesis to the supply from the diet.
Human study
Singhal A et al. (2008). Dietary nucleotides and fecal microbiota in formula-fed infants: a randomized controlled trial. American Journal of Clinical Nutrition 87(6):1785–1792. DOI · PubMed
Study type: randomized controlled trial, infants. In one subgroup (mean age 20 weeks), 35 infants received a nucleotide-enriched formula (31 mg/L) and 37 received a control formula. Forty-four breastfed infants served as the reference group. In stool samples, the ratio of the Bacteroides group to Bifidobacteria was lower in the nucleotide group than in the control group. The authors interpret this as evidence that nucleotides have a beneficial effect on the composition of the gut microbiota in formula-fed infants.
Animal studies and laboratory experiments
Results from animal and laboratory studies cannot be readily applied to humans.
Ding T, Xu M, Li Y (2022). An overlooked prebiotic: beneficial effect of dietary nucleotide supplementation on gut microbiota and metabolites in Prone-8 mice with accelerated senescence. Frontiers in Nutrition 9:820799. DOI · PubMed
Study type: Animal study (mouse) and laboratory experiment. Mice fed a nucleotide-free diet had lower gut microbiota diversity than mice receiving nucleotide supplementation, and the metabolites in their feces also differed. In the laboratory experiment (in vitro), nucleotides promoted the growth of Lactobacillus casei.
Bueno J et al. (1994). Effect of dietary nucleotides on small intestinal repair after diarrhea. Histological and ultrastructural changes. Gut 35(7):926–933. DOI · PubMed
Study type: Animal study (rat). A lactose-rich diet induced chronic diarrhea in weaned young rats. After recovery, the architecture and fine structure of the intestinal mucosa in animals fed a nucleotide-enriched diet were closer to those of healthy control animals. The authors consider it possible that nucleotides are important nutrients for the repair of the intestinal mucosa.
Note: These studies examine nucleotides as a class of compounds, not Colon & Cell. They do not constitute a claim regarding the efficacy of this product.
Good to Know
Frequently Asked Questions About Gut Health
Why have I never heard of nucleotides?
Nucleotides have been known to researchers for decades—as the basic building blocks of DNA and RNA. To the general public, however, they are a relatively new concept, as they were long used primarily in clinical nutrition. Dr. Peter Köppel is one of the pioneers who has made nucleotides accessible for everyday use.
Isn't a healthy diet enough?
During periods of rest, your body produces nucleotides on its own or obtains them from food. When demand increases—for example, during times of stress, after an infection, or while taking antibiotics—the body’s own production is a complex and slow process. That’s exactly when Colon & Cell replenishes the missing building blocks.
How can I restore my gut flora and strengthen my microbiome?
A healthy gut microbiome thrives on diversity: plenty of fiber from legumes and whole-grain products, along with fermented, probiotic foods like sauerkraut or kimchi. These nutrients directly nourish your gut bacteria. Colon & Cell takes a different approach—it targets the gut cells themselves, which form the foundation of a healthy gut microbiome. Both approaches complement each other well.
What is the difference between gut restoration and gut health?
Gut health refers to the overall condition of gut cells, gut bacteria, and digestion—your day-to-day well-being. The term “gut restoration” is usually used in a more specific sense: a treatment regimen lasting several weeks, often following a course of antibiotics or when the gut microbiota is out of balance (dysbiosis), to rebuild gut bacteria and gut cells. The 80-day restoration regimen from Colon & Cell is designed precisely for this targeted restoration.
Who is Colon & Cell suitable for?
For adults who want to specifically support their gut health—especially after antibiotic treatment, during periods of high stress, or as part of a regular regimen.
If you are pregnant, breastfeeding, or taking medication, consult your doctor before taking this product.
How long should I take Colon & Cell?
A treatment course of at least 20 days, taking 3 capsules daily, is recommended. Since the intestinal mucosa renews itself in cycles of 3–5 days, it benefits from a consistent supply of nutrients—the 80-day restorative treatment course is designed to support the complete renewal process.
Can I combine Colon & Cell with other products?
Yes. Colon & Cell can be easily combined with probiotics—the bacteria and nutrients complement each other. It can also be combined with other Vegana-Natura products, such as Immun & Cell.
Is the product vegan and allergen-free?
Colon & Cell is 100% plant-based—including the capsule shell—and is manufactured in Switzerland: GMO-free, free of artificial flavors, free of magnesium stearate, and lab-tested. You can find details about allergens on the label and the product page.
Colon & Cell + Nucleotides
Ready to tackle the root cause?
Give your gut cells what they need to regenerate—high-purity nucleotides developed in Switzerland.
30-day money-back guarantee — no ifs, ands, or buts.
** Notes on Health Claims
Vitamin B2 and biotin help maintain normal mucous membranes.
Folate plays a role in cell division.
Folate contributes to normal cell division.
Vitamin B2 helps protect cells from oxidative stress.
Pantothenic acid and vitamin B2 contribute to normal energy metabolism.
The following statements refer exclusively to the vitamins contained in the product and their authorized health claims in accordance with the Health Claims Regulation (EC) No. 1924/2006.
Nucleotides: The content explains the natural function of nucleotides in the human body. It serves to provide a scientific context for biological relationships and should be considered independently of this dietary supplement. It does not constitute a health claim or a description of the product’s effects.
Statements in the expert quote reflect the personal professional opinion of the respective expert.
Dietary supplements are not a substitute for a balanced, varied diet and a healthy lifestyle. Do not exceed the recommended daily intake. Keep out of the reach of small children.