NukleoPure – Premium Nucleotides in Laboratory-Tested Quality

NukleoPure by Vegana Natura is a premium product for discerning users. The formula is based on 5 individually selected nucleotides of laboratory-tested quality.

Each individual nucleotide is carefully selected, and its composition is verified through defined quality control procedures.

Your Benefits with NukleoPure

• Laboratory-tested quality:  controlled composition and purity
• Single-cell selection:  specifically selected nucleotides
• Defined composition:  Combination of 5 individually selected nucleotides
• Laboratory-tested:  Testing for purity and nucleotide content
• 100% vegan:  no animal-derived ingredients
• No additives:  Focused on the selected ingredients
• Swiss Quality:  Designed and manufactured in Switzerland

Individually Selected Nucleotides – Defined Composition and Verified Quality

NukleoPure features 5 single-cell-selected nucleotides—AMP, CMP, GMP, IMP, and UMP— take center stage.

The individual nucleotides are specifically selected and combined in a defined ratio.

This results in a clearly defined nucleotide formulation with a focus on transparency, purity, and controlled quality.

Nucleotides for Therapists and Discerning Users

NukleoPure is also intended for therapists and professionals who place particular importance on a transparently declared and laboratory-tested nucleotide composition .

The powder form makes it easy to use according to the recommended intake guidelines.

For professionals, we provide detailed product information and available scientific background information upon request.

Who is NukleoPure suitable for?

NukleoPure is suitable for adults who want to specifically supplement their daily diet with nucleotides and value a clearly defined composition.

This product is suitable for anyone who:

• who want to specifically incorporate nucleotides into their daily supplement routine
• prefer a combination of five individually selected nucleotides
• Prioritize transparently declared ingredients
• prefer a vegan formula
• Prioritize laboratory-tested quality
• prefer a nucleotide product in powder form

5 nucleotides. Individually selected. Laboratory-tested.

NukleoPure combines a specific blend of AMP, CMP, GMP, IMP, and UMP with a consistent focus on quality and transparency.

The composition is verified as part of defined quality control procedures.

Premium Nucleotides for Discerning Users.

Detox & Nucleotides – What Our Genes Have to Do With It

Researchers identified 90 genes associated with metabolic, detoxification, and excretion processes. The study thus demonstrates how closely genetic information and the body's metabolic processes are linked.

And this is where nucleotides come into play: Genes are segments of our DNA—and nucleotides are the basic building blocks of that DNA.

The body can produce and recycle nucleotides on its own. However, as we age, nucleotide metabolism and the availability of nucleotides in certain tissues may change —a relationship that is currently being studied by scientists.

The Science Behind Nucleotides

Nucleotides can be produced and recycled in the human body through various metabolic pathways. At the same time, they occur naturally in the body as well as in various foods.

As components of DNA and RNA, nucleotides are the subject of numerous scientific studies.

Scientific Note on Nucleotides

The information on nucleotides is intended to provide scientific background knowledge about their natural occurrence and their function as components of DNA and RNA.

The biological relationships described here should not be interpreted as evidence of any effect of NukleoPure or the nucleotides it contains.

Quality Control – Premium Nucleotides

At NukleoPure, the focus is on a defined composition and controlled quality.

The nucleotide composition is verified as part of the quality control process. Among other things, purity and nucleotide content are analyzed.

This is how NukleoPure 5 individually selected nucleotides with a quality-focused manufacturing and testing process.

For therapists and professionals

Therapists and healthcare professionals can request additional information about NukleoPure from us.

Upon request, we provide detailed product information as well as available scientific background information on nucleotides.

Nucleotides in EU Food Law

Nucleotides are also explicitly recognized as a category of substances in European food law. The Regulation (EU) No. 609/2013lists nucleotides as a separate category of substances alongside vitamins, minerals, and amino acids.

The corresponding Union list includes, among others, AMP, CMP, GMP, IMP, and UMP, as well as their sodium salts,—precisely those nucleotides that are also components of the nucleotide combination inIMMUN & CELL.

Good to know:Regulation (EU) No. 609/2013 applies to certain categories of food, including foods for infants and young children, foods for special medical purposes, and daily rations for weight-control diets. The inclusion of nucleotides in this Union list is therefore not equivalent to a general authorization for dietary supplements.

Sources & studies

Schlosser, P., et al. (2020). Genetic studies of urinary metabolites shed light on mechanisms of detoxification and excretion in humans. *Nature Genetics*, 52, 167–176. The study examined 1,172 metabolites in 1,627 individuals and identified 90 genes that are specifically associated with ADME processes, biotransformation, and detoxification reactions.
Original study in *Nature Genetics*

National Human Genome Research Institute (NHGRI). Nucleotide – Genetics Glossary. Nucleotides are described as the basic building blocks of DNA and RNA.
NHGRI – Nucleotides

 

Consumption recommendation:

Dissolve 1–2 g of the powder in water daily, or mix it into a sports drink or smoothie.

Important information:

Keep out of the reach of small children. Do not exceed the recommended daily dose. Food supplements are not a substitute for a varied diet. Not suitable for people with gout and yeast allergy, after organ transplants or when taking immunosuppressive medication. Store in a cool and dry place.

Sources and scientific studies on nucleotides as food supplements:

• Dietary nucleotides reverse malnutrition and starvation-induced immunosuppression. Pizzini RP, Kumar S, Kulkarni AD, Rudolph FB, Van Buren CT. Arch Surg. 1990 Jan;125(1):86-9; discussion 90. doi: 10.1001/archsurg.1990.01410130092012. PMID: 1688491
• Dietary nucleotides correct plasma and liver microsomal fatty acid alterations in rats with liver cirrhosis induced by oral intake of thioacetamide. Fontana L, Moreira E, Torres MI, Fernández I, Ríos A, Sánchez de Medina F, Gil A. J Hepatol. 1998 Apr;28(4):662-9. doi: 10.1016/s0168-8278(98)80291-2. PMID: 9566836
• Effect of dietary nucleotides on intestinal repair in rats with experimental chronic diarrhea. Nuñez MC, Ayudarte MV, Morales D, Suarez MD, Gil A. JPEN J Parenter Enteral Nutr. 1990 Nov-Dec;14(6):598-604. doi: 10.1177/0148607190014006598. PMID: 2125643
• Dietary nucleotides: cellular immune, intestinal and hepatic system effects. Carver JD. J Nutr. 1994 Jan;124(1 Suppl):144S-148S. doi: 10.1093/jn/124.suppl_1.144S. PMID: 8283305 Review.
• Dietary nucleotides: a conditional requirement. Van Buren CT, Rudolph F. Nutrition. 1997 May;13(5):470-2. doi: 10.1016/s0899-9007(97)00103-2. PMID: 9225342 Review. No abstract available.
• Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats. Cai X, Bao L, Wang N, Ren J, Chen Q, Xu M, Li D, Mao R, Li Y. Food Funct. 2016 Jun 15;7(6):2898-908. doi: 10.1039/c5fo01580e. Epub 2016 Jun 1. PMID: 27247978
• Modulation of the immune response mediated by dietary nucleotides. Gil A. Eur J Clin Nutr. 2002 Aug;56 Suppl 3:S1-4. doi: 10.1038/sj.ejcn.1601475. PMID: 12142952 Review.
• Dietary nucleotides extend the life span in Sprague-Dawley rats. Xu M, Liang R, Guo Q, Wang S, Zhao M, Zhang Z, Wang J, Li Y. J Nutr Health Aging. 2013 Mar;17(3):223-9. doi: 10.1007/s12603-012-0399-z. PMID: 23459974
• Why are dietary nucleotides essential nutrients? Grimble GK. Br J Nutr. 1996 Oct;76(4):475-8. doi: 10.1079/bjn19960056. PMID: 8942356 No abstract available.
• Dietary nucleotides enhance the liver redox state and protein synthesis in cirrhotic rats. Pérez MJ, Sánchez-Medina F, Torres M, Gil A, Suárez A. J Nutr. 2004 Oct;134(10):2504-8. doi: 10.1093/jn/134.10.2504. PMID: 15465738
• Nonimmune system responses to dietary nucleotides. Uauy R. J Nutr. 1994 Jan;124(1 Suppl):157S-159S. doi: 10.1093/jn/124.suppl_1.157S. PMID: 8283307 Review.
• Dietary nucleotides have cytoprotective properties in rat liver damaged by thioacetamide. Torres MI, Fernández MI, Gil A, Ríos A. Life Sci. 1998;62(1):13-22. doi: 10.1016/s0024-3205(97)01033-3. PMID: 9444963
• Effect of dietary nucleotides on small intestinal repair after diarrhea. Histological and ultrastructural changes. Bueno J, Torres M, Almendros A, Carmona R, Nuñez MC, Rios A, Gil A. Gut. 1994 Jul;35(7):926-33. doi: 10.1136/gut.35.7.926. PMID: 8063220 Free PMC article.
• Effect of dietary nucleotides on degree of fibrosis and steatosis induced by oral intake of thioacetamide. Torres MI, Fernandez MI, Gil A, Rios A. Dig Dis Sci. 1997 Jun;42(6):1322-8. doi: 10.1023/a:1018882913983. PMID: 9201102
• Effects of dietary nucleotides on lipid metabolism and learning ability of rats. Sato N, Murakami Y, Nakano T, Sugawara M, Kawakami H, Idota T, Nakajima I. Biosci Biotechnol Biochem. 1995 Jul;59(7):1267-71. doi: 10.1271/bbb.59.1267. PMID: 7670187 Free article.
• Effect of dietary nucleotides on immune function in Balb/C mice. Xu M, Zhao M, Yang R, Zhang Z, Li Y, Wang J. Int Immunopharmacol. 2013 Sep;17(1):50-6. doi: 10.1016/j.intimp.2013.04.032. Epub 2013 May 10. PMID: 23669334
• Dietary nucleotides accelerate intestinal recovery after food deprivation in old rats. Ortega MA, Nunez MC, Gil A, Sánchez-Pozo A. J Nutr. 1995 Jun;125(6):1413-8. doi: 10.1093/jn/125.6.1413. PMID: 7782893
• Dietary nucleotides augment dextran sulfate sodium-induced distal colitis in rats. Sukumar P, Loo A, Adolphe R, Nandi J, Oler A, Levine RA. J Nutr. 1999 Jul;129(7):1377-81. doi: 10.1093/jn/129.7.1377. PMID: 10395601
• Effect of dietary nucleotides on response to bacterial infections. Kulkarni AD, Fanslow WC, Rudolph FB, Van Buren CT. JPEN J Parenter Enteral Nutr. 1986 Mar-Apr;10(2):169-71. doi: 10.1177/0148607186010002169. PMID: 2421021
• Maturation status of small intestine epithelium in rats deprived of dietary nucleotides. Ortega MA, Gil A, Sánchez-Pozo A. Life Sci. 1995;56(19):1623-30. doi: 10.1016/0024-3205(95)00129-t. PMID: 7723591
• Dietary Nucleotides Retard Oxidative Stress-Induced Senescence of Human Umbilical Vein Endothelial Cells. Zhu N, Liu X, Xu M, Li Y. Nutrients. 2021 Sep 20;13(9):3279. doi: 10.3390/nu13093279. PMID: 34579157 Free PMC article.
• Dietary Nucleotides Supplementation and Liver Injury in Alcohol-Treated Rats: A Metabolomics Investigation. Cai X, Bao L, Wang N, Xu M, Mao R, Li Y. Molecules. 2016 Mar 31;21(4):435. doi: 10.3390/molecules21040435. PMID: 27043516 Free PMC article.
• Dietary nucleotides and gut mucosal defense. Grimble GK. Gut. 1994 Jan;35(1 Suppl):S46-51. doi: 10.1136/gut.35.1_suppl.s46. PMID: 8125390 Free PMC article. Review.
• Dietary nucleotides: effects on the immune and gastrointestinal systems. Carver JD. Acta Paediatr Suppl. 1999 Aug;88(430):83-8. doi: 10.1111/j.1651-2227.1999.tb01306.x. PMID: 10569229 Review.
• Anti-fatigue effects of dietary nucleotides in mice. Xu M, Liang R, Li Y, Wang J. Food Nutr Res. 2017 Jun 14;61(1):1334485. doi: 10.1080/16546628.2017.1334485. eCollection 2017. PMID: 28659748 Free PMC article.